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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CASP9
All Species:
11.82
Human Site:
T181
Identified Species:
21.67
UniProt:
P55211
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55211
NP_001220.2
416
46281
T181
E
S
G
L
R
T
R
T
G
S
N
I
D
C
E
Chimpanzee
Pan troglodytes
Q5IS54
277
31588
D70
S
R
S
G
T
D
V
D
A
A
N
L
R
E
T
Rhesus Macaque
Macaca mulatta
XP_001082859
416
46192
T181
E
S
G
L
S
T
R
T
G
S
S
I
D
C
E
Dog
Lupus familis
XP_865164
414
45235
G180
E
S
R
L
T
A
R
G
G
S
N
I
D
C
E
Cat
Felis silvestris
Mouse
Mus musculus
P29594
452
50642
S220
E
K
D
L
E
F
R
S
G
G
D
V
D
H
T
Rat
Rattus norvegicus
P55215
452
50709
S220
E
K
D
L
E
F
R
S
G
G
D
V
D
H
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520982
366
40213
V153
L
L
H
F
E
V
A
V
E
R
N
L
T
A
E
Chicken
Gallus gallus
Q98943
424
47941
S191
E
K
D
L
E
Y
R
S
G
G
D
V
D
C
A
Frog
Xenopus laevis
P55866
282
32106
N75
S
S
N
M
A
V
R
N
G
T
D
V
D
A
L
Zebra Danio
Brachydanio rerio
NP_001007405
436
48445
K192
A
S
E
L
N
D
R
K
G
S
N
I
D
C
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02002
323
35908
L114
L
K
K
A
F
E
N
L
G
F
A
V
S
V
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P42573
503
56598
N260
F
E
Q
M
P
T
R
N
G
T
K
A
D
K
D
Sea Urchin
Strong. purpuratus
XP_799258
437
48470
R182
F
K
T
M
P
P
R
R
G
T
D
I
D
C
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
22.8
93.9
76.9
N.A.
28.9
28.3
N.A.
52.8
31.1
22.6
47.2
N.A.
22.1
N.A.
21.6
32.2
Protein Similarity:
100
35.8
96.8
84.1
N.A.
46.9
46.2
N.A.
65.6
48.3
38.7
64.2
N.A.
35.8
N.A.
37.5
51
P-Site Identity:
100
6.6
86.6
73.3
N.A.
33.3
33.3
N.A.
13.3
40
26.6
60
N.A.
6.6
N.A.
26.6
33.3
P-Site Similarity:
100
20
93.3
73.3
N.A.
53.3
53.3
N.A.
20
60
53.3
66.6
N.A.
13.3
N.A.
46.6
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
8
8
8
0
8
8
8
8
0
16
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
47
0
% C
% Asp:
0
0
24
0
0
16
0
8
0
0
39
0
77
0
16
% D
% Glu:
47
8
8
0
31
8
0
0
8
0
0
0
0
8
31
% E
% Phe:
16
0
0
8
8
16
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
16
8
0
0
0
8
85
24
0
0
0
0
0
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
16
8
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
39
0
0
0
% I
% Lys:
0
39
8
0
0
0
0
8
0
0
8
0
0
8
0
% K
% Leu:
16
8
0
54
0
0
0
8
0
0
0
16
0
0
8
% L
% Met:
0
0
0
24
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
8
0
8
16
0
0
39
0
0
0
0
% N
% Pro:
0
0
0
0
16
8
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
8
0
8
0
77
8
0
8
0
0
8
0
8
% R
% Ser:
16
39
8
0
8
0
0
24
0
31
8
0
8
0
0
% S
% Thr:
0
0
8
0
16
24
0
16
0
24
0
0
8
0
24
% T
% Val:
0
0
0
0
0
16
8
8
0
0
0
39
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _